probucol

Ligand id: 7277

Name: probucol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 91.06
Molecular weight 516.31
XLogP 11.57
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Favari et al. (2005) report that probucol inhibits ABCA1-mediated cholesterol efflux from in vitro cultured mouse J774 cells by 80%, and from human fibroblasts by >50% [2].
Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
ABCA1 Hs Inhibitor Inhibition - - - 2,4
[2,4]
Description: Inhibition of cholesterol efflux from normal human skin fibroblasts, but not from fibroblasts negative in ABCA1.