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Synonyms: DH-581 | Lorelco®
probucol is an approved drug (FDA (1977))
Compound class:
Synthetic organic
Comment: Probucol is a lipid-lowering drug. Marketing of this drug was ceased in 1995 in the US due to safety concerns.
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Bioactivity Comments |
Favari et al. (2005) report that probucol inhibits ABCA1-mediated cholesterol efflux from in vitro cultured mouse J774 cells by 80%, and from human fibroblasts by >50% [2]. |
Selectivity at transporters | ||||||||||||||||||||||||||||||||||
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