probucol

Ligand id: 7277

Name: probucol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 91.06
Molecular weight 516.31
XLogP 11.57
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Favari et al. (2005) report that probucol inhibits ABCA1-mediated cholesterol efflux from in vitro cultured mouse J774 cells by 80%, and from human fibroblasts by >50% [2].
Selectivity at human transporters
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
ABCA1 Inhibitor Inhibition - - - 2,4
[2,4]
Description: Inhibition of cholesterol efflux from normal human skin fibroblasts, but not from fibroblasts negative in ABCA1.