View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments

Favari et al. (2005) report that probucol inhibits ABCA1-mediated cholesterol efflux from in vitro cultured mouse J774 cells by 80%, and from human fibroblasts by >50% [2].

Selectivity at transporters
Key to terms and symbols		Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference ABCA1 Hs Inhibitor Inhibition - - - 2,4 [2,4] Description: Inhibition of cholesterol efflux from normal human skin fibroblasts, but not from fibroblasts negative in ABCA1.