trimipramine

Ligand id: 7317

Name: trimipramine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: trimipramine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 6.48
Molecular weight 294.21
XLogP 5.54
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
SERT Hs Inhibitor Inhibition 6.8 pKi - 1
pKi 6.8 (Ki 1.49x10-7 M) [1]
NET Hs Inhibitor Inhibition 5.6 pKi - 1
pKi 5.6 (Ki 2.45x10-6 M) [1]
DAT Hs Inhibitor Inhibition 5.4 pKi - 1
pKi 5.4 (Ki 3.78x10-6 M) [1]