trimipramine

Ligand id: 7317

Name: trimipramine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: trimipramine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 6.48
Molecular weight 294.21
XLogP 5.54
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat major depressive disorder.
Mechanism Of Action and Pharmacodynamic Effects
The drug's main effects are antagonism of the receptors for the monoamine neurotransmitters dopamine, serotonin, epinephrine/norepinephrine and acetylcholine receptors. Trimipramine is a weak inhibitor of the norepinephrine, serotonin, and dopamine transporters (NET, SLC6A2; SET, SLC6A4; and DAT, SCL6A3 respectively). See the DrugBank link for further details.
External links