Ligand id: 7357

Name: ABT-384

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 91.56
Molecular weight 493.27
XLogP 2.63
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Ki of 9 nM for human truncated 11beta-HSD1 assessed as inhibition of radiolabeled cortisone to cortisol conversion. Slightly more potent against the mouse enzyme [4]. Two active metabolites have been identified [1].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
hydroxysteroid 11-beta dehydrogenase 1 Hs Inhibitor Inhibition 8.1 pKi - 4
pKi 8.1 (Ki 9x10-9 M) [4]