ABT-384

Ligand id: 7357

Name: ABT-384

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 91.56
Molecular weight 493.27
XLogP 2.63
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. An G, Liu W, Katz DA, Marek G, Awni W, Dutta S. (2013)
Effect of ketoconazole on the pharmacokinetics of the 11β-hydroxysteroid dehydrogenase type 1 inhibitor ABT-384 and its two active metabolites in healthy volunteers: population analysis of data from a drug-drug interaction study.
Drug Metab. Dispos.41 (5): 1035-45. [PMID:23431112]
2. Katz DA, Liu W, Locke C, Jacobson P, Barnes DM, Basu R, An G, Rieser MJ, Daszkowski D, Groves F et al.. (2013)
Peripheral and central nervous system inhibition of 11β-hydroxysteroid dehydrogenase type 1 in man by the novel inhibitor ABT-384.
Transl Psychiatry3: e295. [PMID:23982627]
3. Marek GJ, Katz DA, Meier A, Greco 4th N, Zhang W, Liu W, Lenz RA. (2014)
Efficacy and safety evaluation of HSD-1 inhibitor ABT-384 in Alzheimer's disease.
Alzheimers Dement,  [Epub ahead of print]. [PMID:24418055]
4. Sorensen B, Rohde J, Wang J, Fung S, Monzon K, Chiou W, Pan L, Deng X, Stolarik D, Frevert EU et al.. (2006)
Adamantane 11-beta-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction.
Bioorg. Med. Chem. Lett.16 (23): 5958-62. [PMID:16996734]