Ligand id: 7539

Name: naloxegol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 2
Rotatable bonds 24
Topological polar surface area 126.77
Molecular weight 651.36
XLogP -0.06
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Nektar Therapeutics report a Ki of 33.8nM for this compound at the μ-opioid receptor, although these results have not been published. See Nektar Therapeutics Poster 28, Eldon et al, 2007 which was presented at the American Academy of Pain Management 18th Annual Clinical Meeting; September 27–30, 2007; Las Vegas, NV.