naloxegol

Ligand id: 7539

Name: naloxegol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 2
Rotatable bonds 24
Topological polar surface area 126.77
Molecular weight 651.36
XLogP -0.06
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Following from reports of positive results in clinical trials [4], naloxegol has been approved for the treatment of opioid-induced constipation (or opioid-induced bowel dysfunction; OBD).
Mechanism Of Action and Pharmacodynamic Effects
Binding of opioid drugs to μ-opioid receptors in the enteric nervous system is believed to be responsible for opioid-induced constipation [2]. Naloxegol may alleviate this side effect by preventing the drug-receptor interaction at peripheral gut opioid receptors [1,3].