Ligand id: 7574

Name: dupilumab

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Affinity data in the table below is taken from patent US7608693 [2], using antibody clone H4H098P as a representative example of the embodiment of the patent. The clone becoming dupilumab is not reported.
Selectivity at catalytic receptors
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Target Sp. Type Action Affinity Units Concentration range (M) Reference
Interleukin-4 receptor subunit α Hs Antibody Binding 11.1 pIC50 - 2
pIC50 11.1 (IC50 8.8x10-12 M) [2]
Description: Value derived from an ELISA-based solution competition assay.