ocrelizumab

Ligand id: 7580

Name: ocrelizumab

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Ocrelizumab depletes CD20+ B cells in the blood and lymphoid tissues of cynomolgus monkeys (Macaca fascicularis) [4]. B cell numbers recover to normal levels after one or two treatments [4]. Affinity data for clone 2H7.v16 is presented below. Clone 2H7.v31 exhibited 20-fold higher antibody-dependent cell-mediated cytotoxicity (ADCC) than the approved anti-CD20 monoclonal rituximab.
Selectivity at human other protein targets
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Target Type Action Affinity Units Concentration range (M) Reference
CD20 (membrane-spanning 4-domains, subfamily A, member 1) Antibody Binding 9.1 pKd - 1
pKd 9.1 (Kd 8.4x10-10 M) [1]