Ligand id: 7678

Name: AZD8529

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 83.73
Molecular weight 487.18
XLogP 3.91
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
IC50 and HERG binding are listed for 6 analogues in US20080306077 [2].
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
mGlu2 receptor Hs Allosteric modulator Positive 6.7 pEC50 - 1
pEC50 6.7 (EC50 1.95x10-7 M) [1]