Ligand id: 7725

Name: AZ12260493

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 78.1
Molecular weight 439.19
XLogP 6.35
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Pending publication, the data presented here is derived from the compound's record in AstaZeneca's Open Innovation Pharmacology Toolbox
Selectivity at nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Liver X receptor-α Hs Agonist Agonist 8.1 pKi - 1
pKi 8.1 (Ki 7x10-9 M) [1]
Liver X receptor-β Hs Agonist Agonist 8.0 pKi - 2
pKi 8.0 (Ki 1.1x10-8 M) [2]