Liver X receptor-β

Nomenclature: Liver X receptor-β

Systematic Nomenclature: NR1H2

Family: 1H. Liver X receptor-like receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species AA Chromosomal Location Gene Symbol Gene Name Reference
Human 461 19q13.3-q13.3 NR1H2 nuclear receptor subfamily 1, group H, member 2 26
Mouse 446 7 B3 Nr1h2 nuclear receptor subfamily 1, group H, member 2 25
Rat 443 1q22 Nr1h2 nuclear receptor subfamily 1, group H, member 2 27
Previous and Unofficial Names
NER
NER-I
RIP15
LXR-b
LXRβ
Oxysterols receptor β
ubiquitously expressed nuclear receptor
UNR
ubiquitously-expressed nuclear receptor
liver X receptor-beta
Unr2
OR-1
UR
liver X receptor beta
nuclear orphan receptor LXR-beta
nuclear receptor subfamily 1, group H, member 2
orphan nuclear receptor OR-1
oxysterols receptor LXR-beta
ubiquitous receptor
LXRbeta
LXRB
AI194859
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
NURSA Receptor
OMIM
PharmGKB Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  LXR-beta ligand binding domain
PDB Id:  1UPV
Ligand:  T0901317
Resolution:  2.1Å
Species:  Human
References:  8
Natural/Endogenous Ligands
Comments: A series of oxysterols are natural ligands
Potency order (Human)
20S-hydroxycholesterol, 22R-hydroxycholesterol, 24(S)-hydroxycholesterol > 25-hydroxycholesterol, 27-hydroxycholesterol  [16]
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
L-783483 Hs Agonist 8.2 pKd 20
pKd 8.2 [20]
acetyl-podocarpic dimer Hs Agonist 9.0 pEC50 28
pEC50 9.0 [28]
GW3965 Hs Agonist 7.52 pEC50 3
pEC50 7.52 [3]
T0901317 Hs Agonist 7.3 pEC50 24
pEC50 7.3 [24]
27-hydroxycholesterol Hs Agonist 7.15 pEC50 6
pEC50 7.15 [6]
24(S), 25-epoxycholesterol Hs Agonist 5.52 pEC50 16
pEC50 5.52 [16]
22R-hydroxycholesterol Hs Agonist 5.52 pEC50 11
pEC50 5.52 [11]
24(S)-hydroxycholesterol Hs Agonist 5.5 pEC50 16
pEC50 5.5 [16]
DNA Binding
Structure:  RXR partner
HRE core sequence:  AGGTCANNNNAGGTCA
Response element:  DR1
DNA Binding Comments
RXR binds the 5’ hexamer while LXR binds the 3’ hexamer of DR4s. LXR/RXR heterodimer is reported to also bind DR1s in reverse orientation.
Co-binding Partners
Name Interaction Effect Reference
Retinoid X receptor-α Physical 25
SHP Physical, Functional 2
Main Co-regulators
Name Activity Specific Ligand dependent AF-2 dependent Comments References
NCOA1 Co-activator No Yes No 21
EP300 Co-activator No Yes No 10
NCOR1 Co-activator No Yes No 9
NCOR2 None No Yes No 9
Main Target Genes
Name Species Effect Technique Comments References
ABCA1 Human Activated Transient transfection, EMSA 4,23
SREBF1 Human Activated Transient transfection, EMSA 22
ABCG1 Human Activated Transient transfection, EMSA 13,29
CPOC1 Human Activated Transient transfection 19
APOC2 Human Activated Transient transfection 19
APOC4 Human Activated Transient transfection 19
APOE Human Activated Transient transfection, EMSA 15
CETP Human Activated Transient transfection, EMSA 18
NR1H3 Human Activated Transient transfection, EMSA 14
FAS Human Activated Transient transfection, EMSA 12
SLC2A4 Human Activated Transient transfection, EMSA 5
VEGF Human Activated 30
Tissue Distribution
Ubiquitous
Species:  Rat
Technique:  Northern Blot
References:  17,27
Physiological Consequences of Altering Gene Expression
LXRβ knock-out mice
Species:  Mouse
Tissue: 
Technique:  Knock-out
References:  1,7
Physiological Consequences of Altering Gene Expression Comments
Normal resistance to dietary cholesterol, unlike the LXRα KO. LXRβ KO mice are also reported to show alterations in adipocyte growth, glucose homeostasis and beta cell function.
Phenotypes, Alleles and Disease Models Mouse data from MGI

Show »

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0002182 abnormal astrocyte morphology PMID: 12368482 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0009278 abnormal bone marrow cell physiology PMID: 12193651 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0010152 abnormal brain ependyma morphology PMID: 12368482 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0004950 abnormal brain vasculature morphology PMID: 12368482 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0000822 abnormal brain ventricle morphology PMID: 12368482 
Nr1h2tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352463  MP:0003191 abnormal cellular cholesterol metabolism PMID: 11238557 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0005537 abnormal cerebral aqueduct morphology PMID: 12368482 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0005278 abnormal cholesterol homeostasis PMID: 12368482 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0000820 abnormal choroid plexus morphology PMID: 12368482 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0001119 abnormal female reproductive system morphology PMID: 17166844 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0003699 abnormal female reproductive system physiology PMID: 17166844 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0000828 abnormal fourth ventricle morphology PMID: 12368482 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0000823 abnormal lateral ventricle morphology PMID: 12368482 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0002786 abnormal Leydig cell morphology PMID: 17341595 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0002118 abnormal lipid homeostasis PMID: 12368482 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0002446 abnormal macrophage morphology PMID: 12193651 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0001145 abnormal male reproductive system morphology PMID: 17166844 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0003698 abnormal male reproductive system physiology PMID: 17166844 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0009229 abnormal median eminence morphology PMID: 12368482 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0000920 abnormal myelination PMID: 12368482 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0003871 abnormal myelin sheath morphology PMID: 12368482 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0008256 abnormal myometrium morphology PMID: 17166844 
Nr1h2tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm
involves: 129/Sv * C57BL/6
MGI:1352463  MP:0008256 abnormal myometrium morphology PMID: 17166844 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0002907 abnormal parturition PMID: 17166844 
Nr1h2tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm
involves: 129/Sv * C57BL/6
MGI:1352463  MP:0002907 abnormal parturition PMID: 17166844 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0002216 abnormal seminiferous tubule morphology PMID: 17341595 
Nr1h2+|Nr1h2tm1.1Gstr|Rxrb+|Rxrbtm1Mma Nr1h2tm1.1Gstr/Nr1h2+,Rxrbtm1Mma/Rxrb+
involves: 129 * C57BL/6
MGI:1352463  MGI:98215  MP:0002784 abnormal Sertoli cell morphology PMID: 14993927 
Nr1h2tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr
involves: 129 * C57BL/6
MGI:1352463  MP:0002784 abnormal Sertoli cell morphology PMID: 14993927 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0002784 abnormal Sertoli cell morphology PMID: 17341595 
Nr1h2tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm
involves: 129/Sv * C57BL/6
MGI:1352463  MP:0002784 abnormal Sertoli cell morphology PMID: 17341595 
Nr1h2tm1Dgen Nr1h2tm1Dgen/Nr1h2tm1Dgen
B6.129-Nr1h2
MGI:1352463  MP:0001533 abnormal skeleton physiology PMID: 20133709 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0002685 abnormal spermatogonia proliferation PMID: 17341595 
Nr1h2tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm
involves: 129/Sv * C57BL/6
MGI:1352463  MP:0002685 abnormal spermatogonia proliferation PMID: 17341595 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0009688 abnormal spinal cord central canal morphology PMID: 12368482 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0000836 abnormal substantia nigra morphology PMID: 12368482 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0000826 abnormal third ventricle morphology PMID: 12368482 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0009671 abnormal uterus physiology PMID: 17166844 
Nr1h2tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm
involves: 129/Sv * C57BL/6
MGI:1352463  MP:0009671 abnormal uterus physiology PMID: 17166844 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0008934 absent choroid plexus PMID: 12368482 
Nr1h2tm1Djm|Tg(APPswe,PSEN1dE9)85Dbo Nr1h2tm1Djm/Nr1h2tm1Djm,Tg(APPswe,PSEN1dE9)85Dbo/0
involves: 129/Sv * C3H * C57BL/6
MGI:1352463  MGI:3525178  MP:0003329 amyloid beta deposits PMID: 17563384 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0003354 astrocytosis PMID: 12368482 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0002773 decreased circulating luteinizing hormone level PMID: 17341595 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0002780 decreased circulating testosterone level PMID: 17341595 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0008948 decreased neuron number PMID: 12368482 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0004852 decreased testis weight PMID: 17341595 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0000755 hindlimb paralysis PMID: 17166844 
Nr1h2tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm
involves: 129/Sv * C57BL/6
MGI:1352463  MP:0000755 hindlimb paralysis PMID: 17166844 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0000740 impaired smooth muscle contractility PMID: 17166844 
Nr1h2tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm
involves: 129/Sv * C57BL/6
MGI:1352463  MP:0000740 impaired smooth muscle contractility PMID: 17166844 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac
MGI:1352462  MGI:1352463  MP:0010027 increased liver cholesterol level PMID: 10968783 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0004778 increased macrophage derived foam cell number PMID: 12368482 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0009763 increased sensitivity to induced morbidity/mortality PMID: 12524534 
Nr1h2tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm
involves: 129/Sv * C57BL/6
MGI:1352463  MP:0009763 increased sensitivity to induced morbidity/mortality PMID: 12524534 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0002412 increased susceptibility to bacterial infection PMID: 12524534 
Nr1h2tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm
involves: 129/Sv * C57BL/6
MGI:1352463  MP:0002412 increased susceptibility to bacterial infection PMID: 12524534 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0001915 intracranial hemorrhage PMID: 12368482 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0008280 male germ cell apoptosis PMID: 17341595 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0003224 neuron degeneration PMID: 12368482 
Nr1h2tm1Gstr Nr1h2tm1Gstr/Nr1h2tm1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352463  MP:0002169 no abnormal phenotype detected PMID: 11238557 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0008028 pregnancy-related premature death PMID: 17166844 
Nr1h2tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm
involves: 129/Sv * C57BL/6
MGI:1352463  MP:0008028 pregnancy-related premature death PMID: 17166844 
Npc1m1N|Nr1h2tm1Djm Npc1m1N/Npc1m1N,Nr1h2tm1Djm/Nr1h2tm1Djm
involves: BALB/c
MGI:1097712  MGI:1352463  MP:0002083 premature death PMID: 18160655 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0001922 reduced male fertility PMID: 17341595 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0001154 seminiferous tubule degeneration PMID: 17341595 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0003205 testicular atrophy PMID: 17341595 
Nr1h2tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm
Not Specified
MGI:1352463  MP:0001218 thin epidermis PMID: 11851872 

References

Show »

1. Alberti S, Schuster G, Parini P, Feltkamp D, Diczfalusy U, Rudling M, Angelin B, Björkhem I, Pettersson S, Gustafsson JA. (2001) Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice. J. Clin. Invest.107 (5): 565-73. [PMID:11238557]

2. Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J. (2002) The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity. Mol. Endocrinol.16 (9): 2065-76. [PMID:12198243]

3. Collins JL, Fivush AM, Watson MA, Galardi CM, Lewis MC, Moore LB, Parks DJ, Wilson JG, Tippin TK, Binz JG, Plunket KD, Morgan DG, Beaudet EJ, Whitney KD, Kliewer SA, Willson TM. (2002) Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J. Med. Chem.45 (10): 1963-6. [PMID:11985463]

4. Costet P, Luo Y, Wang N, Tall AR. (2000) Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J. Biol. Chem.275 (36): 28240-5. [PMID:10858438]

5. Dalen KT, Ulven SM, Bamberg K, Gustafsson JA, Nebb HI. (2003) Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha. J. Biol. Chem.278 (48): 48283-91. [PMID:12970362]

6. Fu X, Menke JG, Chen Y, Zhou G, MacNaul KL, Wright SD, Sparrow CP, Lund EG. (2001) 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J. Biol. Chem.276 (42): 38378-87. [PMID:11504730]

7. Gerin I, Dolinsky VW, Shackman JG, Kennedy RT, Chiang SH, Burant CF, Steffensen KR, Gustafsson JA, MacDougald OA. (2005) LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function. J. Biol. Chem.280 (24): 23024-31. [PMID:15831500]

8. Hoerer S, Schmid A, Heckel A, Budzinski RM, Nar H. (2003) Crystal structure of the human liver X receptor beta ligand-binding domain in complex with a synthetic agonist. J. Mol. Biol.334 (5): 853-61. [PMID:14643652]

9. Hu X, Li S, Wu J, Xia C, Lala DS. (2003) Liver X receptors interact with corepressors to regulate gene expression. Mol. Endocrinol.17 (6): 1019-26. [PMID:12663743]

10. Huuskonen J, Fielding PE, Fielding CJ. (2004) Role of p160 coactivator complex in the activation of liver X receptor. Arterioscler. Thromb. Vasc. Biol.24 (4): 703-8. [PMID:14764426]

11. Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ. (1996) An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature383 (6602): 728-31. [PMID:8878485]

12. Joseph SB, Laffitte BA, Patel PH, Watson MA, Matsukuma KE, Walczak R, Collins JL, Osborne TF, Tontonoz P. (2002) Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. J. Biol. Chem.277 (13): 11019-25. [PMID:11790787]

13. Kennedy MA, Venkateswaran A, Tarr PT, Xenarios I, Kudoh J, Shimizu N, Edwards PA. (2001) Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein. J. Biol. Chem.276 (42): 39438-47. [PMID:11500512]

14. Laffitte BA, Joseph SB, Walczak R, Pei L, Wilpitz DC, Collins JL, Tontonoz P. (2001) Autoregulation of the human liver X receptor alpha promoter. Mol. Cell. Biol.21 (22): 7558-68. [PMID:11604492]

15. Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, Tontonoz P. (2001) LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc. Natl. Acad. Sci. U.S.A.98 (2): 507-12. [PMID:11149950]

16. Lehmann JM, Kliewer SA, Moore LB, Smith-Oliver TA, Oliver BB, Su JL, Sundseth SS, Winegar DA, Blanchard DE, Spencer TA, Willson TM. (1997) Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J. Biol. Chem.272 (6): 3137-40. [PMID:9013544]

17. Lu TT, Repa JJ, Mangelsdorf DJ. (2001) Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism. J. Biol. Chem.276 (41): 37735-8. [PMID:11459853]

18. Luo Y, Tall AR. (2000) Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element. J. Clin. Invest.105 (4): 513-20. [PMID:10683381]

19. Mak PA, Laffitte BA, Desrumaux C, Joseph SB, Curtiss LK, Mangelsdorf DJ, Tontonoz P, Edwards PA. (2002) Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta. J. Biol. Chem.277 (35): 31900-8. [PMID:12032151]

20. Menke JG, Macnaul KL, Hayes NS, Baffic J, Chao YS, Elbrecht A, Kelly LJ, Lam MH, Schmidt A, Sahoo S, Wang J, Wright SD, Xin P, Zhou G, Moller DE, Sparrow CP. (2002) A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a). Endocrinology143 (7): 2548-58. [PMID:12072387]

21. Otte K, Kranz H, Kober I, Thompson P, Hoefer M, Haubold B, Remmel B, Voss H, Kaiser C, Albers M, Cheruvallath Z, Jackson D, Casari G, Koegl M, Pääbo S, Mous J, Kremoser C, Deuschle U. (2003) Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. Mol. Cell. Biol.23 (3): 864-72. [PMID:12529392]

22. Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ. (2000) Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev.14 (22): 2819-30. [PMID:11090130]

23. Repa JJ, Turley SD, Lobaccaro JA, Medina J, Li L, Lustig K, Shan B, Heyman RA, Dietschy JM, Mangelsdorf DJ. (2000) Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science289 (5484): 1524-9. [PMID:10968783]

24. Schultz JR, Tu H, Luk A, Repa JJ, Medina JC, Li L, Schwendner S, Wang S, Thoolen M, Mangelsdorf DJ, Lustig KD, Shan B. (2000) Role of LXRs in control of lipogenesis. Genes Dev.14 (22): 2831-8. [PMID:11090131]

25. Seol W, Choi HS, Moore DD. (1995) Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol. Endocrinol.9 (1): 72-85. [PMID:7760852]

26. Shinar DM, Endo N, Rutledge SJ, Vogel R, Rodan GA, Schmidt A. (1994) NER, a new member of the gene family encoding the human steroid hormone nuclear receptor. Gene147 (2): 273-6. [PMID:7926814]

27. Song C, Kokontis JM, Hiipakka RA, Liao S. (1994) Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors. Proc. Natl. Acad. Sci. U.S.A.91 (23): 10809-13. [PMID:7971966]

28. Sparrow CP, Baffic J, Lam MH, Lund EG, Adams AD, Fu X, Hayes N, Jones AB, Macnaul KL, Ondeyka J, Singh S, Wang J, Zhou G, Moller DE, Wright SD, Menke JG. (2002) A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux. J. Biol. Chem.277 (12): 10021-7. [PMID:11790770]

29. Venkateswaran A, Repa JJ, Lobaccaro JM, Bronson A, Mangelsdorf DJ, Edwards PA. (2000) Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols. J. Biol. Chem.275 (19): 14700-7. [PMID:10799558]

30. Walczak R, Joseph SB, Laffitte BA, Castrillo A, Pei L, Tontonoz P. (2004) Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors. J. Biol. Chem.279 (11): 9905-11. [PMID:14699103]

How to cite this page

1H. Liver X receptor-like receptors: Liver X receptor-β. Last modified on 13/12/2013. Accessed on 24/10/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=601.