Ligand id: 7745

Name: daporinad

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 62.3
Molecular weight 391.23
XLogP 5.44
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Daporinad (FK866) inhibits NAMPT with an Ki value of 0.4nM [2]. In vitro treatment of patient-derived chronic lymphocytic leukemia (CLL) cells with daporinad induces apoptotic cell death via depletion of NAD+ [1], and may offer an additional clinical tool to combat this currently incurable disease.