daporinad

Ligand id: 7745

Name: daporinad

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 62.3
Molecular weight 391.23
XLogP 5.44
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
Inhibition of NAMPT leads to a slow depletion of NAD+ and promotes delayed cell death by apoptosis [2]. This compound exploits a novel mechanism with potential value in the fight against cancers which are difficult to treat with currently available therapeutics