Synonyms: APO-866 | FK-866 | FK866
Compound class:
Synthetic organic
Comment: FK866 is a highly specific non-competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT; P43490) [2], an enzyme required for the biosynthesis of nicotinamide adenine dinucleotide (NAD+).
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
References |
1. Gehrke I, Bouchard ED, Beiggi S, Poeppl AG, Johnston JB, Gibson SB, Banerji V. (2014)
On-Target Effect of FK866, a Nicotinamide Phosphoribosyl Transferase Inhibitor, by Apoptosis-Mediated Death in Chronic Lymphocytic Leukemia Cells. Clin Cancer Res, 20 (18): 4861-72. [PMID:25172933] |
2. Hasmann M, Schemainda I. (2003)
FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res, 63 (21): 7436-42. [PMID:14612543] |