dusigitumab   Click here for help

GtoPdb Ligand ID: 7749

Synonyms: MEDI-573
Compound class: Antibody
Comment: Dusigitumab is an investigational monoclonal antibody which neutralises circulating insulin-like growth factor (IGF)-I and IGF-2. These growth factors regulate cell growth, survival, differentiation, and transformation. Antibody-mediated ligand neutralisation prevents these growth hormones from activating signalling via both IGF1R and IR-A (insulin receptor isoform A, Uniprot identifier P06213-2, RefSeq protein NP_001073285).
Peptide sequence alignment suggests that dusigitumab is antibody 7-159-1 in patent US7939637 [2].
Bioactivity Comments
Despite peptide matches suggesting that dusigitumab is antibody 7_159_1 (or 7.159.1) in patent US7939637 [2], no data is presented for this clone. Data is presented for 7.159.2, but crucially no sequence data is available. The binding data we present here is for antibody clone 7.159.2 as a representative example from the patent.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
insulin-like growth factor 2 Primary target of this compound Hs Antibody Binding 11.5 pKd - 2
⤷ pKd 11.5 (Kd 2.9x10-12 M) [2]
insulin-like growth factor 1 Primary target of this compound Hs Antibody Binding 9.7 pKd - 2
⤷ pKd 9.7 (Kd 2.16x10-10 M) [2]