Ligand id: 7805

Name: AZ4800

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 83.32
Molecular weight 435.23
XLogP 3.24
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
The effect of AZ4800 on Aβ peptide generation has been measured in HEK/APPswe cells. AZ4800 (and AZ3303 and AZ1136) reduced Aβ40 as well as Aβ42 but appeared 2–15-fold more potent in reducing Aβ42 levels.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
presenilin 1 Hs Inhibitor Inhibition 7.6 pIC50 - 1
pIC50 7.6 (IC50 2.6x10-8 M) [1]