AZ4800

Ligand id: 7805

Name: AZ4800

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 83.32
Molecular weight 435.23
XLogP 3.24
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-(cyclopentyloxymethyl)-N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-amine
Synonyms
AZ 4800 | AZ-4800
Database Links
ChEMBL Ligand CHEMBL2151176
PubChem CID 50996844
Search Google for chemical match using the InChIKey RMRFSIAFQBYBSN-UHFFFAOYSA-N
Search Google for chemicals with the same backbone RMRFSIAFQBYBSN
Search UniChem for chemical match using the InChIKey RMRFSIAFQBYBSN-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone RMRFSIAFQBYBSN
Comments
AZD4800 is one of several AstraZeneca gamma secretase modulators [1]. It has recently been used for targeting amyloid β production in a mouse model of Alzheimer's disease (AD) in combination with the BACE1 inhibitor AZ3971 [2].