DQP-1105

Ligand id: 7843

Name: DQP-1105

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 99.4
Molecular weight 557.1
XLogP 6.79
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
DQP-1105 is approximately 50-fold selective for GluN2C or GluN2D subunit-containing NMDA receptors compared to GluN2A- or GluN2B-containing receptors [1].
Selectivity at rat ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
GluN2C Allosteric modulator Negative 8.1 pIC50 - 1
pIC50 8.1 (IC50 7x10-9 M) [1]
Description: Measured using recombinant GluN1-1a NMDA subunits co-expressed with GluN2C subunits.
GluN2B Allosteric modulator Negative 6.9 pIC50 - 1
pIC50 6.9 (IC50 1.13x10-7 M) [1]
Description: Measured using recombinant GluN1-1a NMDA subunits co-expressed with GluN2C subunits.
GluN2D Allosteric modulator Negative 5.6 pIC50 - 1
pIC50 5.6 (IC50 2.7x10-6 M) [1]
Description: Measured using recombinant GluN1-1a NMDA subunits co-expressed with GluN2D subunits.