DQP-1105

Ligand id: 7843

Name: DQP-1105

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 99.4
Molecular weight 557.1
XLogP 6.79
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
DQP-1105 is approximately 50-fold selective for GluN2C or GluN2D subunit-containing NMDA receptors compared to GluN2A- or GluN2B-containing receptors [1].
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
GluN2C Rn Allosteric modulator Negative 8.1 pIC50 - 1
pIC50 8.1 (IC50 7x10-9 M) [1]
Description: Measured using recombinant GluN1-1a NMDA subunits co-expressed with GluN2C subunits.
GluN2B Rn Allosteric modulator Negative 6.9 pIC50 - 1
pIC50 6.9 (IC50 1.13x10-7 M) [1]
Description: Measured using recombinant GluN1-1a NMDA subunits co-expressed with GluN2C subunits.
GluN2D Rn Allosteric modulator Negative 5.6 pIC50 - 1
pIC50 5.6 (IC50 2.7x10-6 M) [1]
Description: Measured using recombinant GluN1-1a NMDA subunits co-expressed with GluN2D subunits.