Ligand id: 7979

Name: dinutuximab

Bioactivity Comments
A binding affinity value is not presented in the associated patent US 20140170155 [4].
Soman et al (2012) [6] report an affinity (Kd) for FcγRIIIA binding by dinutuximab of approximately 500nM, measured using BIACore surface plasmon resonance methodology. Fcγ binding is a measure of the antibody's ability to induce antibody-dependent cell-mediated cytotoxicity (ADCC). A Ka for the originally identified murine anti-GD2 antibody 14.18 is provided by Mujoo et al (1987) [5]. Converting this to a Kd gives a value of 0.03nM which is an approximation of the binding affinity of the chimeric human (ch14.18) antibody that is dinutuximab..