Ligand id: 8027

Name: AZD3409

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 17
Topological polar surface area 142.95
Molecular weight 574.24
XLogP 6.43
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Bioactivity Comments
AZD3409 inhibits cell growth of several cancer cell lines, MDA-MB-231, BT-474, A2780 and A2780cp, with IC50 values of 19.2, 5.7, 3.2, and 8.9 μM respectively [3]. In MEF H-Ras(V12) cells it has a cytotoxic IC50 of 510nM [1].