pemtumomab

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Ligands
pemtumomab

GtoPdb Ligand ID: 8031

Synonyms: HMFG1 | HuHMFG-1 [2]

Comment: Pemtumomab is a monoclonal antibody directed against a specific antigenic epitope (PDTR sequence in the MUC1 tandem repeat [5]) of the mucin 1 (MUC1) expressed by several types of secretory epithelial-derived cancers [4]. MUC1 is a large, heavily glycosylated mucin. It is expressed on the apical surface of the most secretory epithelial cells [1] and an antigenically distinct form of MUC1 is overexpressed in 90% of adenocarcinomas, including cancers of the ovary, breast, and pancreas. This means that antibodies can be targeted to cancerous cells [3,5], sparing normal tissue. Pemtumomab is labelled with the radioisotope yttrium-90.
This antibody does not appear to have an INN (international non-proprietary name), and no peptide sequences are available.

Bioactivity Comments
In vitro, exposure to HuHMFG-1 induces a strong antibody-dependent cell-mediated cytotoxicity (ADCC) against several MUC1 expressing cell lines [5]. Binding affinity data is provided in patent US20060193849, but the specific antibody clone becoming HuHMFG-1 is not specified [2], and due to the unavailability of peptide sequences BLAST searching is impossible. Antibody clones tested for the patent submission exhibited K_d values of 103-199nM [2].

Bioactivity Comments

In vitro, exposure to HuHMFG-1 induces a strong antibody-dependent cell-mediated cytotoxicity (ADCC) against several MUC1 expressing cell lines [5]. Binding affinity data is provided in patent US20060193849, but the specific antibody clone becoming HuHMFG-1 is not specified [2], and due to the unavailability of peptide sequences BLAST searching is impossible. Antibody clones tested for the patent submission exhibited K_d values of 103-199nM [2].