|
Synonyms: HMFG1 | HuHMFG-1 [2]
Compound class:
Antibody
Comment: Pemtumomab is a monoclonal antibody directed against a specific antigenic epitope (PDTR sequence in the MUC1 tandem repeat [5]) of the mucin 1 (MUC1) expressed by several types of secretory epithelial-derived cancers [4]. MUC1 is a large, heavily glycosylated mucin. It is expressed on the apical surface of the most secretory epithelial cells [1] and an antigenically distinct form of MUC1 is overexpressed in 90% of adenocarcinomas, including cancers of the ovary, breast, and pancreas. This means that antibodies can be targeted to cancerous cells [3,5], sparing normal tissue. Pemtumomab is labelled with the radioisotope yttrium-90.
This antibody does not appear to have an INN (international non-proprietary name), and no peptide sequences are available. |
Classification  |
|
| Compound class | Antibody |
| Synonyms |
|
| HMFG1 | HuHMFG-1 [2] | |
| Database Links |
|
| GtoPdb PubChem SID | 249565711 |
| Wikipedia | Pemtumomab |
