Ligand id: 8250

Name: BLZ945

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 124.61
Molecular weight 398.14
XLogP 2.92
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
In a kinase panel screen only three interactions with this compound were identified, CSF1R, cKIT and PDGFRβ, but selectivity for CSF1R is >3800-fold [2] (see Supplementary Figure S2). The highly selective nature of this compound limits its off-target activities which is common when targeting this kinase subfamily, so this should increase the interperatability of results from animal studies.
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
colony stimulating factor 1 receptor Hs Inhibitor Inhibition 9.0 pIC50 - 2
pIC50 9.0 (IC50 1x10-9 M) [2]
KIT proto-oncogene receptor tyrosine kinase Hs Inhibitor Inhibition 5.4 pIC50 - 2
pIC50 5.4 (IC50 3.88x10-6 M) [2]
platelet derived growth factor receptor beta Hs Inhibitor Inhibition 5.2 pIC50 - 2
pIC50 5.2 (IC50 5.86x10-6 M) [2]