example 7 [US8664233]

Ligand id: 8283

Name: example 7 [US8664233]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 78.96
Molecular weight 374.19
XLogP 2.47
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Bioactivity Comments
Patent US8664233 [1] does not directly measure the ability of this compound to inhibit PDE4B activity, but reports biologically relevant outputs such as apoptotic activity (activation of caspases 3, 7 and 9), cellular toxicity (IC50 80nM), and the substance's hemolytic effect.