example 7 [US8664233]

Ligand id: 8283

Name: example 7 [US8664233]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 78.96
Molecular weight 374.19
XLogP 2.47
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
The EMA granted this compound orphan drug designation in 2007, for the treatment of chronic lymphocytic leukemia (CLL).
Mechanism Of Action and Pharmacodynamic Effects
This compound acts as an inhibitor of phosphodiesterase E4 (gene symbol PDE4B), a cyclic adenosine monophosphate (cAMP) degrading enzyme expressed in CLL cells. Enzyme inhibition causes a rise in intracellular levels of cAMP which is believed to result in cell death.