Ligand id: 8305

Name: tucidinostat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 97.11
Molecular weight 390.15
XLogP 3.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Bioactivity Comments
Efficacy of chidamide has been measured using in vitro cytotoxicity, histone acetylation and signalling pathway activation assays. An IC50 or Ki for HDAC inhibition is not available. We have tagged HDAC1 as the pimary molecular target of this drug for data metrics purposes only, and in no way suggest that this in the only target of this drug.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
histone deacetylase 1 Hs Inhibitor Inhibition - - - 3
Ligand mentioned in the following text fields