tucidinostat

Ligand id: 8305

Name: tucidinostat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 97.11
Molecular weight 390.15
XLogP 3.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Dong M, Ning ZQ, Xing PY, Xu JL, Cao HX, Dou GF, Meng ZY, Shi YK, Lu XP, Feng FY. (2012)
Phase I study of chidamide (CS055/HBI-8000), a new histone deacetylase inhibitor, in patients with advanced solid tumors and lymphomas.
Cancer Chemother. Pharmacol.69 (6): 1413-22. [PMID:22362161]
2. Gong K, Xie J, Yi H, Li W. (2012)
CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells.
Biochem. J.443 (3): 735-46. [PMID:22339555]
3. Liu L, Chen B, Qin S, Li S, He X, Qiu S, Zhao W, Zhao H. (2010)
A novel histone deacetylase inhibitor Chidamide induces apoptosis of human colon cancer cells.
Biochem. Biophys. Res. Commun.392 (2): 190-5. [PMID:20060381]
4. Qiao Z, Ren S, Li W, Wang X, He M, Guo Y, Sun L, He Y, Ge Y, Yu Q. (2013)
Chidamide, a novel histone deacetylase inhibitor, synergistically enhances gemcitabine cytotoxicity in pancreatic cancer cells.
Biochem. Biophys. Res. Commun.434 (1): 95-101. [PMID:23541946]
5. Wang H, Guo Y, Fu M, Liang X, Zhang X, Wang R, Lin C, Qian H. (2012)
Antitumor activity of Chidamide in hepatocellular carcinoma cell lines.
Mol Med Rep5 (6): 1503-8. [PMID:22484326]
6. Yao Y, Zhou J, Wang L, Gao X, Ning Q, Jiang M, Wang J, Wang L, Yu L. (2013)
Increased PRAME-specific CTL killing of acute myeloid leukemia cells by either a novel histone deacetylase inhibitor chidamide alone or combined treatment with decitabine.
PLoS ONE8 (8): e70522. [PMID:23940586]