DZNep

Ligand id: 8392

Name: DZNep

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 117.42
Molecular weight 264.12
XLogP -0.77
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
DZNep inhibits purified hamster liver preparation of S-adenosylhomocysteine hydrolase with a Ki of 0.5pM [1]. The molecular mechanism underlying inhibition of EZH2 activity is reported to be due to increased protein degradation, rather than direct enzyme inhibition [2].
Selectivity at hamster enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
S-Adenosylhomocysteine hydrolase Inhibitor Inhibition 12.3 pKi - 1
pKi 12.3 (Ki 5x10-13 M) [1]
Description: Inhibition of a SAHH preparation isolated from hamster liver.