Ligand id: 8735

Name: avelumab

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
A patent search identifies that peptide sequences of the heavy and light chains of avelumab are identical to SEQ ID NO: 24 and SEQ ID NO: 25 (respectively) in WO2013079174 A1 [1]. The data in the table below is that proovided for clone A09-246-2, a preferred embodiment of the patent.
Selectivity at human ligand targets
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
programmed cell death 1 ligand 1 Antibody Binding 10.1 pIC50 - 1
pIC50 10.1 (IC50 7.1x10-11 M) [1]
Description: Measuring inhibition of PD-1 binding to PD-L1.