combretastatin A4

Ligand id: 8854

Name: combretastatin A4

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 57.15
Molecular weight 316.13
XLogP 3.38
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Inhibits colchicine binding to tubulin with an apparent Ki of 140nM [3].
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
tubulin beta 3 class III Hs Inhibitor Inhibition 8.2 pIC50 - 1
pIC50 8.2 (IC50 5.7x10-9 M) [1]
Description: Measuring cytotoxicity in cells expressing TUBB3 using the sulforhodamine B colorimetric assay.