combretastatin A4

Ligand id: 8854

Name: combretastatin A4

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 57.15
Molecular weight 316.13
XLogP 3.38
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Two Phase III clinical trials of fosbretabulin in patients with anaplastic thyroid cancer were terminated/withdrawn. Phase II trials in other solid tumours, polypoidal choroidal vasculopathy, and age-related macular degeneration (AMD) are ongoing or have been completed.