glembatumumab vedotin

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Ligands
glembatumumab vedotin

GtoPdb Ligand ID: 8926

Synonyms: CDX-011 | CR011-vcMMAE

Comment: Glembatumumab vedotin is a fully human anti-gpNMB (transmembrane glycoprotein NMB; gene symbol GPNMB) monoclonal antibody-drug conjugate (ADC) carrying the antineoplastic toxin monomethyl auristatin E (MMAE; PubChem CID 11542188). Development and preclinical evaluation of this ADC is reported in [4].
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

Summary
Biological activity
Clinical data
References

Bioactivity Comments
The unconjugated antibody (designated CDX-011) binds to a purified gpNMB peptide (representing just the extracellular domain) with a K_d of 52nM [4]. The unconjugated antibody does not inhibit melanoma cell proliferation [4].

Bioactivity Comments

The unconjugated antibody (designated CDX-011) binds to a purified gpNMB peptide (representing just the extracellular domain) with a K_d of 52nM [4].
The unconjugated antibody does not inhibit melanoma cell proliferation [4].