evocalcet

Ligand id: 9042

Name: evocalcet

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 52.57
Molecular weight 374.2
XLogP 6.67
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Bioactivity Comments
Peer reviewed, freely accessible data supporting evolacet's molecular interaction with the CASR is not available. US8362274 only provides EC50 data for a few of the claimed compounds, but not for this specific example (3.008) [1]. Given the data in the patent, it is likely evocalcet's EC50 will be in the mid nanomolar range.
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
CaS receptor Agonist Agonist - - - 1
[1]