Ligand id: 9042

Name: evocalcet

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 52.57
Molecular weight 374.2
XLogP 6.67
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Evocalcet (KHK7580) is being evaluated in Phase III clinical trial for the treatment of hemodialysis patients with secondary hyperparathyroidism. Click here to link to ClinicalTrials.gov's full list of KHK7580 trials.
Mechanism Of Action and Pharmacodynamic Effects
CASR agonists act to suppress parathyroid hormone (PTH) production.