BMS-986124

Ligand id: 9160

Name: BMS-986124

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 80.29
Molecular weight 446.94
XLogP 4.31
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
BMS-986124 blocks the effects of the μ opioid receptor positive allosteric modulator BMS-986122, but does not affect binding or activities of orthosteric μ receptor agonists such as endomorphin-1 or DAMGO [2].
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
μ receptor Allosteric modulator Neutral 5.7 pKB - 2
pKB 5.7 (KB 2x10-6 M) [2]