CGI560

Ligand id: 9264

Name: CGI560

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 71.32
Molecular weight 461.22
XLogP 8.92
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
CGI560 exhibits > ten-fold selectivity over a panel of 16 kinases.
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Bruton tyrosine kinase Inhibitor Inhibition 6.4 pIC50 - 2
pIC50 6.4 (IC50 4x10-7 M) [2]