BU08028   Click here for help

GtoPdb Ligand ID: 9294

Synonyms: compound 1b [PMID: 21866885]
Compound class: Synthetic organic
Comment: BU08028 is a novel research compound that provides the pain relief of opiates, without their addictive effects in mouse models of acute pain and cocaine-induced reward [1-2]. Structurally it is a derivative of buprenorphine, with only the addition of an additional methylene group at the C20 substituent. Increasing affinity for the NOP receptor is predicted to reduce the behavioural side-effects associated with buprenorphine.
Note that the compound referred to as 1b in [1] has a marginally different stereo compared to the same compound (named as BUB8028) in [2], with identical data provided for 1b and BUB8028 in both articles. Compound 1b resolves to PubChem CID 56664973. We have chosen to link to CID 50922685 as the specified stereochemistry of this is identical to that of buprenorphine.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 62.16
Molecular weight 481.32
XLogP 4.13
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES COC12CCC3(CC1C(C(CC)(C)C)(O)C)C14C2Oc2c4c(CC3N(CC1)CC1CC1)ccc2O
Isomeric SMILES CO[C@]12CC[C@]3(C[C@@H]1[C@@](C(CC)(C)C)(O)C)[C@@]14[C@H]2Oc2c4c(C[C@H]3N(CC1)CC1CC1)ccc2O
InChI InChI=1S/C30H43NO4/c1-6-26(2,3)27(4,33)21-16-28-11-12-30(21,34-5)25-29(28)13-14-31(17-18-7-8-18)22(28)15-19-9-10-20(32)24(35-25)23(19)29/h9-10,18,21-22,25,32-33H,6-8,11-17H2,1-5H3/t21-,22-,25-,27+,28-,29+,30-/m1/s1
InChI Key HBENZIXOGRCSQN-VQWWACLZSA-N
Bioactivity Comments
BU08028 is a high affinity pan-opioid receptor agonist (in radioligand binding assays), but has only partial agonist activity at the μ, δ and NOP receptors (in GTPγS binding assays) [2]. BU08028 does not stimulate GTPγS binding to the κ receptor.
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
δ receptor Hs Agonist Partial agonist 8.8 pKi - 2
⤷ pKi 8.8 (Ki 1.59x10-9 M) [2]
μ receptor Hs Agonist Partial agonist 8.7 pKi - 2
⤷ pKi 8.7 (Ki 2.14x10-9 M) [2]
κ receptor Hs Agonist Agonist 8.3 pKi - 2
⤷ pKi 8.3 (Ki 5.63x10-9 M) [2]
NOP receptor Hs Agonist Partial agonist 8.1 pKi - 2
⤷ pKi 8.1 (Ki 8.46x10-9 M) [2]