Ligand id: 9294

Name: BU08028

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 62.16
Molecular weight 481.32
XLogP 4.44
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
BU08028 is a high affinity pan-opioid receptor agonist (in radioligand binding assays), but has only partial agonist activity at the μ, δ and NOP receptors (in GTPγS binding assays) [2]. BU08028 does not stimulate GTPγS binding to the κ receptor.
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
δ receptor Hs Agonist Partial agonist 8.8 pKi - 2
pKi 8.8 (Ki 1.59x10-9 M) [2]
μ receptor Hs Agonist Partial agonist 8.7 pKi - 2
pKi 8.7 (Ki 2.14x10-9 M) [2]
κ receptor Hs Agonist Agonist 8.3 pKi - 2
pKi 8.3 (Ki 5.63x10-9 M) [2]
NOP receptor Hs Agonist Partial agonist 8.1 pKi - 2
pKi 8.1 (Ki 8.46x10-9 M) [2]