AZD7545

Ligand id: 9362

Name: AZD7545

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 112.16
Molecular weight 478.06
XLogP 2.41
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
AZD7545 eliminates postprandial elevation in blood glucose in obese rats, thereby improving glucose control [1]. AZD7545 shows modest selectivity (<6-fold) for PDHK2 over PDHK1 but does not inhibit PDHK4 [1].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
pyruvate dehydrogenase kinase 2 Inhibitor Inhibition 8.2 pIC50 - 2
pIC50 8.2 (IC50 6.4x10-9 M) [2]
Description: In a biochemical enzyme assay
pyruvate dehydrogenase kinase 1 Inhibitor Inhibition 7.4 pIC50 - 2
pIC50 7.4 (IC50 3.68x10-8 M) [2]
Description: In a biochemical enzyme assay