Ligand id: 9362

Name: AZD7545

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 112.16
Molecular weight 478.06
XLogP 2.4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
Inhibition of PDHK2 increases pyruvate dehydrogenase (PDH) activity, PDH activity being key to controlling the rate of glucose oxidation. Activation of PDH is predicted to increase glucose uptake and reduce glucose production, thereby improving control of blood glucose levels.