AZ3451

Ligand id: 9560

Name: AZ3451

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 89.17
Molecular weight 570.13
XLogP 7.4
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
PAR2 Allosteric modulator Negative 7.9 pKd - 1
pKd 7.9 (Kd 1.35x10-8 M) [1]
Description: In a BIACORE assay.
PAR2 Allosteric modulator Negative 7.6 – 8.3 pIC50 - 1
pIC50 8.3 (IC50 5.4x10-9 M) [1]
Description: In a FLIPR calcium accumulation assay, vs. SLIGRL activation.
pIC50 7.6 (IC50 2.3x10-8 M) [1]
Description: Antagonism of SLIGRL-NH2-induced IP1 formation.