ER-27319   Click here for help

GtoPdb Ligand ID: 9611

Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: The structure shown here is ER-27319 free base, when in fact the biological activity has been evaluated using the ethanedioate as represented by PubChem CID 9799508 [1]. ER-27319 is an inhibitor of spleen tyrosine kinase (Syk) [2] however, given the high concentration of compound ER-27319 required to cause half-maximal inhibition of mast cells degranulation, targets other than Syk may also be inhibited. In addition ER-27319 targets the activation of SYK mediated through FcεR1γ ITAM, suggesting there is no direct interaction with the Syk ATP pocket. Whatever the mechanism ER-27319 action is specific to mast cells.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 48.02
Molecular weight 280.16
XLogP 5.12
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES NCCCn1c2ccccc2c(=O)c2c1c(C)c(C)cc2
Isomeric SMILES NCCCn1c2ccccc2c(=O)c2c1c(C)c(C)cc2
InChI InChI=1S/C18H20N2O/c1-12-8-9-15-17(13(12)2)20(11-5-10-19)16-7-4-3-6-14(16)18(15)21/h3-4,6-9H,5,10-11,19H2,1-2H3
InChI Key CFPDEQBPNROZDC-UHFFFAOYSA-N
Bioactivity Comments
ER-27319 selectively interferes with FcεRI gamma phospho-ITAM activation of Syk in vitro and in intact cells [1].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
spleen associated tyrosine kinase Hs Inhibitor Inhibition 5.0 pIC50 - 2
⤷ pIC50 5.0 (IC50 1x10-5 M) [2]
Description: Inhibition of Syk in human mast cells by immunoprecipitation assay