Ligand id: 9611

Name: ER-27319

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 46.33
Molecular weight 280.16
XLogP 3.98
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
ER-27319 selectively interferes with FcεRI gamma phospho-ITAM activation of Syk in vitro and in intact cells [1].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
spleen associated tyrosine kinase Hs Inhibitor Inhibition 5.0 pIC50 - 2
pIC50 5.0 (IC50 1x10-5 M) [2]
Description: Inhibition of Syk in human mast cells by immunoprecipitation assay