Ligand id: 9611

Name: ER-27319

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 46.33
Molecular weight 280.16
XLogP 3.98
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Moriya K, Rivera J, Odom S, Sakuma Y, Muramato K, Yoshiuchi T, Miyamoto M, Yamada K. (1997)
ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of fcepsilon receptor I-mediated activation of Syk.
Proc. Natl. Acad. Sci. U.S.A., 94 (23): 12539-44. [PMID:9356485]
2. Singh R, Masuda ES, Payan DG. (2012)
Discovery and development of spleen tyrosine kinase (SYK) inhibitors.
J. Med. Chem., 55 (8): 3614-43. [PMID:22257213]