Ligand id: 102

Name: yohimbine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 65.56
Molecular weight 354.19
XLogP 2.86
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Yohimbine is a mydriatic agent, meaning that it causes the pupil of the eye to dilate. Topical mydriatic agents such as yohimbine are applied to the eye to assist during eye examination and to treat inflammatory eye conditions such as iritis and cyclitis. Yohimbine may be used to treat impotence.
Mechanism Of Action and Pharmacodynamic Effects
Inhibits pre-synaptic α2-adrenoceptors. Yohimbine also has mild monoamine oxidase inhibitory action.