triptorelin

Ligand id: 1177

Name: triptorelin

Structure and Physico-chemical Properties

2D Structure
No information available.
Summary of Clinical Use
Extended-release formulations containing triptorelin pamoate are approved for the treatment of various indications including advanced stage prostate cancer, endometriosis, uterine fibroids and GnRH-dependent central precocious puberty (CPP), and are also used in in vitro fertilization programs. TriptodurTM is an extended-release formulation administered at 6 month intervals for CPP.
Mechanism Of Action and Pharmacodynamic Effects
Triptorelin is a peptide agonist analogue of gonadotropin-releasing hormone (GnRH). When given continuously triptorelin down-regulates GnRH receptor activity, thereby inhibiting the release of the gonadotrophins, LH and FSH. This results in a marked reduction of testicular (and ovarian) steroidogenesis.
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