Ligand id: 1222

Name: cetirizine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 53.01
Molecular weight 388.16
XLogP 4.21
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Cetirizine is used to control the symptoms of allergic rhinitis, chronic urticaria, and pollen-induced asthma. It does not cause the drowsiness associated with some other antihistamines. In many countries this drug is available without a prescription. An ophthalmic solution containing cetirizine hydrochloride (0.24%, Zerviate®) was FDA approved in June 2017.
Mechanism Of Action and Pharmacodynamic Effects
Cetirizine is a potent histamine H1 receptor antagonist.
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