eglumegad

Ligand id: 1393

Name: eglumegad

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 100.62
Molecular weight 185.07
XLogP -3.39
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Eglumegad (LY354740) is a research drug being investigated for efficacy in the treatment of anxiety [3,8] and drug addiction [5].
Mechanism Of Action and Pharmacodynamic Effects
A glutamate derivative, eglumegad is a selective agonist for the group II metabotropic glutamate receptors (mGluR2/3) [1,9]. These receptors reduce the activity of postsynaptic potentials in the cortex by inhibiting the release of glutamate and GABA. This class of drug represents a novel mechanism of action in treating anxiety, as such compounds appear to have no reproducible interaction with dopamine D2 receptors, which are an established drug target in psychosis.