eglumegad

Ligand id: 1393

Name: eglumegad

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 100.62
Molecular weight 185.07
XLogP -3.39
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Bond A, Monn JA, Lodge D. (1997)
A novel orally active group 2 metabotropic glutamate receptor agonist: LY354740.
Neuroreport8 (6): 1463-6. [PMID:9172154]
2. Cartmell J, Adam G, Chaboz S, Henningsen R, Kemp JA, Klingelschmidt A, Metzler V, Monsma F, Schaffhauser H, Wichmann J, Mutel V. (1998)
Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxy-cyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes.
Br J Pharmacol.123: 497- 504. [PMID:9504391]
3. Dunayevich E, Erickson J, Levine L, Landbloom R, Schoepp DD, Tollefson GD. (2008)
Efficacy and tolerability of an mGlu2/3 agonist in the treatment of generalized anxiety disorder.
Neuropsychopharmacology33 (7): 1603-10. [PMID:17712352]
4. Johnson BG, Wright RA, Arnold MB, Wheeler WJ, Ornstein PL, Schoepp DD. (1999)
[3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells.
Neuropharmacology.38: 1519- 1529. [PMID:10530814]
5. Kłodzińska A, Chojnacka-Wójcik E, Pałucha A, Brański P, Popik P, Pilc A. (1999)
Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models.
Neuropharmacology38 (12): 1831-9. [PMID:10608278]
6. Malherbe P, Kratzeisen C, Lundstrom K, Richards JG, Faull RLM, Mutel V. (1999)
Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8.
Brain Res. Mol. Brain Res.67: 201-210. [PMID:10216218]
7. Monn JA, Valli MJ, Massey SM, Hansen MM, Kress TJ, Wepsiec JP, Harkness AR, Grutsch JL, Wright RA, Johnson BG, Andis SL, Kingston A, Tomlinson R, Lewis R, Griffey KR, Tizzano JP, Schoepp DD. (1999)
Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors.
J Med Chem.42: 1027- 1040. [PMID:10090786]
8. Pilc A. (2003)
LY-354740 (Eli Lilly).
IDrugs6 (1): 66-71. [PMID:12789623]
9. Schoepp DD, Johnson BG, Wright RA, Salhoff CR, Mayne NG, Wu S, Cockerman SL, Burnett JP, Belegaje R, Bleakman D et al.. (1997)
LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors.
Neuropharmacology36 (1): 1-11. [PMID:9144636]
10. Schweitzer C, Kratzeisen C, Adam G, Lundstrom K, Malherbe P, Ohresser S, Stadler H, Wichmann J, Woltering T, Mutel V. (2000)
Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using semliki forest virus vectors.
Neuropharmacology.39: 1700- 1706. [PMID:10884552]