Ligand id: 1628

Name: nalmefene

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 52.93
Molecular weight 339.18
XLogP 1.55
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
This drug was approved in 1995 by the US FDA to treat narcotic addiction/overdose, but this approval has since been discontinued. The EMA has approved nalmefene to help reduce alcohol consumption in adults with alcohol dependence.
Mechanism Of Action and Pharmacodynamic Effects
Nalmefene antagonises the activity of the opioid receptors in the brain which play a role in addiction. This helps to reduce the urge to drink in people accustomed to large amounts of alcohol [2]. There is some evidence to suggest this anti-addiction effect may help pathological gambling addiction [3].
External links