Ligand id: 1628

Name: nalmefene

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 52.93
Molecular weight 339.18
XLogP 1.55
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Toll L, Berzetei-Gurske IP, Polgar WE, Brandt SR, Adapa ID, Rodriguez L, Schwartz RW, Haggart D, O'Brien A, White A, Kennedy JM, Craymer K, Farrington L, Auh JS. (1998)
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.

NOTE: This paper is available through the website of the International Narcotics Research Conference, at
NIDA Res Monogr, 178: 440-466. [PMID:9686407]
2. van den Brink W, Sørensen P, Torup L, Mann K, Gual A, SENSE Study Group. (2014)
Long-term efficacy, tolerability and safety of nalmefene as-needed in patients with alcohol dependence: A 1-year, randomised controlled study.
J. Psychopharmacol. (Oxford), 28 (8): 733-44. [PMID:24671340]
3. Yip SW, Potenza MN. (2014)
Treatment of Gambling Disorders.
Curr Treat Options Psychiatry, 1 (2): 189-203. [PMID:24904757]